EYECRYL PLUS ™ (Clear Aspheric with Hydrophobic Surface Lens)

Hydrophobic Surface Acrylic Foldable IOL with Delivery System

Description: (design concept of aspheric IOL)

Conventional spherical IOLS have positive spherical aberrations resulting in decreased contrast sensitivity.

First generation aspherical IOLs have negative spherical aberrations. These IOLs are not universally acceptable because of higher order aberrations (HOAs) in case of decentration or tilting of lens.

Eyecryl Plus Aspheric Series IOLs are aberration free IOLs with aspheric anterior and posterior surfaces. The aberration free design provides good performance and vision even in case of zonular weakness, decentrated pupils and tilting of lens. (Eyecryl Plus Aspheric Series IOLs have been tested for +0.5 mm of decentration and 5 Degree of tilting). The visual function in mesopic/low light conditions improves drastically.

Diopter range - We offer a full range of available Diopter from - 20.00D to +50.00D, in 0.50d increments under Special Manufacturing.

As shown in the diagrams below, incase of Eyecryl Plus Aspheric Series IOL, the diopter remains uniform from central optical zone to the optical edge, whereas incase of conventional spherical IOL diopter shift is evident outside the central optical zone of 3.0 mm.

Technical Specifications:

Model	EYECRYL PLUS HSAS 600	EYECRYL PLUS HSAS 4X4
Lens Material	Foldable acrylate and UV-absorber	Foldable acrylate and UV-absorber
Refractive Index	1.462	1.462
Optic Size	6.0 mm	6.0 mm
Overall Size	12.5mm	11.0mm
A Constant	118.0	118.0
ACD	4.96	4.96
Angle	5°	5°
Diopter Range	+5 To 30 D	+5 To 30 D
Edge Type	360° Square Eddge	360° Square Eddge

Hydrophobic Surface Modification:

Surface modification offers a hydrophillic lens with surface properties similar to hydrophobic lens without changing the bulk properties of the IOL material.

The idea behind surface modification of Hydrophillic IOL is to make it more hydrophobic & render it less attractive to cell attachment and cell growth.

Hydrophollic acrylic material has a proven clinical history and acceptability within ophthalmic segment. We are providing a major advantage to this material by providing a permanent hydrophollic acrylic polymer.

Advantages of Surface modified IOLs:

• Surface which is permanent in nature & technology that has proven its effectiveness is many implantable medical devices
• Higher contact angle increases hydrophobicity
• Smooth lens surface prevents bacterial adhesion
• Lower surface energy inhibits cell growth & cell adherence thus postponing the secondary cataract
• Resistance to silicon oil adherence
• Reduced inflammatory cell response
• Optical Purity-no vacuoles
• High Biocompatibility
• Facilities placement of the lens and reduces trauma to the patient by allowing for a smaller incision during surgery
• Implantation withourt substantial risk of corneal endothelial cell damage
• Insensitive to atmospheric temperature changes as compared to hydrophobic IOLs
• Less attractive to airborn particles particles in operational field
• Cost effective

Contact Angle:

Hydrophobicity can be monitored by water contact angle measurement a sessible drop method (contact angle increases in case of surface modified IOLs). Contact angle prevails about 35° - 45° incase of conventional hydrophobic IOL, which increases up to 75° - 85° in case of surface modified hydrophobic IOL. Pictures of measuring contact angle are:

Refraction Value:

The Refraction value mentioned on the lens label is the actual value of measurement after all the manufacturing processes (including surface modification of hydrophobic lenses).

EYECRYL PLUS ™ (Natural Yellow Aspheric with Hydrophobic Surface Lens)

Hydrophobic Surface Modified

Advanced Aspheric IOLs with excellent visual outcomes:

Features:

• Hydrophobic Surface Modified IOL with Aspheric Optic
• Asphericity on Anterior surface of the IOL
• Aberration free optic
• 360 degrees Square Surface
• Enhances Contrast Sensitivity, Sharpness and Clarity at night
• Exact refractive value of the IOL is printed along with deopter on the box to facilitate the surgeon to choose nearest diopter that matches to A-Scan biometry result
• Optical Purity, No vacuoles
• Smooth lense surface reduces bacterial adhesion and inflamatort cell response
• Reduces PCO

With blue light filter - An optimal solution for retina protection

Eyecryl Plus Natural Yellow Series contains a unique covalently bound natural chromophore, which contains the same UV A blocking and Blue light Filtering chromophore that is in the human crystalline lens. We use nature's own solutions to the problem of protecting the retina from harmful energetic light. The absorption spectrum of 3 HydroxyKynurenine (Figure 1) shows that this natural compound is an excellent UV A blocker with a secondary purpose of filtering violet and blue light. This compound and its beta Glucoside derivatives are nature's primary protection for UV A and violet blue light.

We have made a special monomer identical to the naturally occurring chromophore and covalently incorporated it into our lens material. The visible transmission spectrum of our natural yellow lens material is shown below (Figure 2) compared to the transmission spectrum of a young human crystalline lens as defined by Van De Kraats and Van Norren1. Using nature's chromophore also provides natural protection while maintaining high contrast sensitivity.

Thus, Eyecryl Plus Natural Yellow Series provide blue light filtering similar to a young natural lens.

EYECRYL PLUS ™ (Natural Yellow Hydrophilic Lens)

Advanced Aspheric IOLs with excellent visual outcomes:

EYECRYL PLUS ™  (Hydrophobic Surface Lens)

Acrylic Foldable IOL with Delivery System

Description: (design concept of Hydrophobic Surface Modification)

Surface modification offers a hydrophillic lens with surface properties similar to hydrophobic lens without changing the bulk properties of the IOL material.

The idea behind surface modification of Hydrophillic IOL is to make it more hydrophobic and render it less attractive to cell attachment and cell growth.

Hydrophillic acrylic material has a proven clinical history and acceptability within Ophthalmic segment. We are providing a major advantage to this material by providing a permanent hydrophobic outer surface without changing the physiochemical and other typical properties of hydrophillic acrylic polymer.

Advantages of Surface modified IOLs:

• Surface which is permanent in nature and technology that has proven its effectiveness in many implantable medical devices
• Higher contact angle increases hydrophobicity
• Smooth lens surface prevents bacterial adhesion
• Lower surface energy inhibits cell growth and cell adherence thus postponing the secondary cataract
• Resistance to silicon oil adherence
• Reduced inflammatory cell response
• Optical Purity-no vacuoles
• High Biocompatilbility
• Facilities placement of the lens and reduces trauma to the patient by allowing for a smaller incision during surgery
• Implantation withourt substantial risk of corneal endothelial cell damage
• Insensitive to atmospheric temperature changes as compared to hydrophobic IOLs
• Less attractive to airborn particles particles in operational field
• Cost effective

Comparative Chart:

Contact Angle:

Hydrophobicity can be monitored by water contact angle measurement a sessile drop method ( contact angle increases in case of surface modified IOLs). Contact angle prevails about 35 - 45 incase of conventional hydrophilic IOL, which increases up to 75 - 85 in case of surface modified hydrophillic IOL.

Refraction Value:

The refraction value mentioned on the lens label is the actual value of measurement after all the manufacturing processes (including surface modification of hydrophillic lenses).

EYECRYL PLUS ™  (Accommodative Hydrophobic Surface Lens)

Hydrophobic Surface Acrylic Foldable IOL with Delivery System

Description: (design concept of Accomodative IOL)

Since the evolution of cataract surgery, the ultimate goal of cataract surgeon has been to provide unaided, high quality vision for distance, intermediate and near objects including every point in between. Eyecryl Plus HSATF575 is an accommodative lens plus CTR with a revolutionary design which is based on Hemholtz's theory of accommodation and addresses the problem of pseudophakic presbyopia fully and satisfactorily.

This IOL allows implantation through a standard phacoemulsification incision of sub 2.6 mm. The six haptics design with anterior vaulting allows the lens to move accommodate, to focus on objects near, far and at all distances in between without any hysterisis. The posteriorly vaulted haptics ensure minimum adhesion to anterior subcapsular cells for a longer period to maintain accommodation effect.

As a unique feature, the gap between six haptics diminishes during capsular bag contraction process to form a continuous CTR to postpone PCO.

As shown in the diagram below, during normal conditions (far focus), the curvature (angle) of the lens is reduced by the flattened capsular bag membrane and enlarges the overall focal distances of lens. Accomodation is accomplished by contraction of the ciliary body and subsequent release in the resting tension of the zonular fibres by which the crystalline lens is suspended, resulting in anterior movement of the optic creating a change in focus. The curvature of the optic also increases during this process, providing further change in focus as shown in fig: 1.2 and fig: 1.3.

Estimated axial displacement will be 0.25 - 1.0 mm resulting in accommodation over 1.5D.

Accomodative + MF IOL

HSATF575 MF is an accommodative + Multifocal IOL, which provides accommodation by axial movement of the lens and pseudoaccomodation by multifocal rings. In addition to the accommodation upto 1.5 D (approx.) , 3.0 D diopter addition is provided by the near diopter zone.

Details:

• Central Ring 0 - 1.5 mm : far vision
• Annular Ring 1.5 - 2.3 mm : near vision
• Peripherry 2.3 - 5.75 mm : distance vision

Hydrophobic Surface Modification:

Surface modification offers a hydrophillic lens with surface properties similar to hydrophobic lens without changing the bulk properties of the IOL material.

The idea behind surface modification of Hydrophillic IOL is to make it more hydrophobic and render it less attractive to cell attachment and cell growth.

Hydrophillic acrylic material has a proven clinical history and acceptability within Ophthalmic segment. We are providing a major advantage to this material by providing a permanent hydrophobic outer surface without changing the physiochemical and other typical properties of hydrophillic acrylic polymer.

Technical Specifications:

Advantages of Surface modified IOLs:

• Surface which is permanent in nature and technology that has proven its effectiveness in many implantable medical devices
• Higher contact angle increases hydrophobicitySmooth lens surface prevents bacterial adhesion
• Lower surface energy inhibits cell growth and cell adherence thus postponing the secondary cataract
• Resistance to silicon oil adherence
• Reduced inflammatory cell response
• Optical Purity-no vacuoles
• High Biocompatibility
• Facilitates placement of the lens and reduces trauma to the patient by allowing for a smaller incision during surgery
• Implantation without substantial risk of corneal endothelial cell damage
• Insensitive to atmospheric temperature changes as compared to hydrophobic IOLs
• Less attractive to airborn particles in operational field
• Cost effective

Contact Angle:

Hydrophobicity can be monitored by water contact angle measurement a sessile drop method ( contact angle increases in case of surface modified IOLs). Contact angle prevails about 35° - 45° incase of conventional hydrophillic IOL, which increases upto 75°° - 85° in case of surface modified hydrophillic IOL. Pictures of measuring contact angle are:

Refraction Value:

The refraction value mentioned on the lens label is the actual value of measurement after all the manufacturing processes (including surface modification of hydrophillic lenses).

EYECRYL PLUS ™  (Micro Thin Foldable Lens)

Micro-Eyecryl Acrylic lens For Micro-Phaco Acrylic 25% CQ UV

We are among the few manufacturers producing over 1.5 million Intraocular Lenses per annum, with 70% of our capacity being utilised for the export market

MICRO-EYECRYL is our extremely thin, foldable, flexible, lens.

We have technology that allows the manufacture of lenses with powers of +10 D to +30 D, with a thickness of only 500-700 µm. The MicroThin Foldable technology is achieved by an evolutionary optic design and a unique manufacturing process. The lens is made from hydrophilic material similar to IOL materials already in the market.

Technical Specifications:

Advantages:

• The basic advantage of the lens is that it is ultra-thin with no compromise of optical quality.
• A 6 mm optimised optic to reduce aberrations and thickness.
• A 10.6mm outer diametere to 'fit' in the bag at once.
• An optimised haptics shape to drive any vault backwards, if any.
• A 'fish-tail back' optical edge design.

Image below shows the micro-surgical procedure for Micro Eyecryl:

EYECRYL / Clearvision 600

Foldable Acrylic for Phaco (Acrylic 26% CQ UV)

Technical Specifications:

Material	Acrylic 26% CQ UV
Refractive Index	1.462
Optical Shape	Biconvex
Type	One piece IOL
Optical Diameter	6.00 mm with "Fish Tail" back optical edge
Overall Diameter>	12.50 mm
Vault	5°
Estimated A Constant	118.0
A.C. Depth	4.96 mm
Power Range (in diopter)	From -5.0 to +30.0 (by ½ diopter from +15.0 to +25.0)
Sterilisation	By Steam Sterilization
Indication	Phacoemulsification
Implantation Site	Capsular Bag

EYECRYL / Clearvision 600-ROH

Foldable Acrylic for Phaco (Acrylic 26% CQ UV)

Technical Specifications:

EYECRYL 600 L

Foldable Acrylic for Phaco (Acrylic 26% CQ UV)

Technical Specifications:

Material	Acrylic 26% CQ UV
Refractive Index	1.462
Optical Shape	Biconvex
Type	One piece IOL
Optical Diameter	6.00 mm with "Fish Tail" back optical edge
Overall Diameter	13.50 mm
Vault	5°
Estimated A Constant	118.0
A.C. Depth	4.96 mm
Power Range (in diopter)	From -5.0 to +30.0 (by ½ diopter from +15.0 to +25.0)
Sterilisation	By Steam Sterilization
Indication	Phacoemulsification
Implantation Site	Capsular Bag

EYECRYL 600 LMF

Foldable Multifocal Acrylic for Phaco (Acrylic 26% CQ UV)

Technical Specifications:

EYECRYL TP 600 (Foldable Acrylics)

Foldable Multifocal Acrylic for Phaco (Acrylic CQ UV)

Technical Specifications:

EYECRYL 4 x 4 600

Foldable Acrylic for Phaco (Acrylic 26% CQ UV)

Technical Specifications:

Material	Acrylic 26% CQ UV
Refractive Index	1.462
Optical Shape	Biconvex
Type	One piece IOL
Optical Diameter	6.00 mm with "Fish Tail" back optical edge
Overall Diameter	11.0 mm
Vault	5°
Estimated A Constant	118.0
A.C. Depth	4.96 mm
Power Range (in diopter)	From -5.0 to +30.0 (by ½ diopter from +15.0 to +25.0)
Sterilisation	By Steam Sterilization
Indication	Phacoemulsification
Implantation Site	Capsular Bag

EYECRYL PLUS

Features:

• Allows implantation through sub 2.6 mm incision size
• Packed in medical grade, biocompatible double blister packaging
• Endotoxin level bellow 0.25 EU/IOL

Comparative Analysis of Different EYECRYL Models:

Packaging

Eyecryl PLUS is supplied in double blister pack to ensure that the outer surface of the inner blister/vial (containing product) remains sterile while usage of product. Please open the outer blister in sterile environment. Now open the blister / vial on the operation table.

Bio Holder Folder

The Holder-Folder made of Medical grade pre-oriented PEI material is specially designed to deliver foldable lenses with ease. It not only holds the lens during implant but also has a locking device which folds the lens, facilitating surgery.

Packaging of Eyecryl Acrylic Lenses